Arterial spin labeling versus BOLD in direct challenge and drug-task interaction pharmacological fMRI
نویسندگان
چکیده
منابع مشابه
Arterial spin labeling versus BOLD in direct challenge and drug-task interaction pharmacological fMRI
A carefully controlled study allowed us to compare the sensitivity of ASL (arterial spin labeling) and BOLD (blood oxygen level dependent) fMRI for detecting the effects of the adenosine A2a antagonist tozadenant in Parkinson disease. The study compared the effect of drug directly or the interaction of the drug with a cognitive task. Only ASL detected the direct effect of tozadenant. BOLD was m...
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Functional magnetic resonance imaging (fMRI) has become the most widely used modality for visualizing regional brain activation in response to sensorimotor or cognitive tasks. While the majority of fMRI studies have used blood oxygenation level-dependent (BOLD) contrast as a marker for neural activation, baseline drift effects result in poor sensitivity for detecting slow variations in neural a...
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ژورنال
عنوان ژورنال: PeerJ
سال: 2014
ISSN: 2167-8359
DOI: 10.7717/peerj.687